What Does The Science Say About CBD For Improving Brain Function For Those Living With Alzheimer’s Disease?
A study found that high doses of the cannabis extract helped restore the function of two proteins which are key to reducing the accumulation of beta-amyloid plaque, a hallmark of Alzheimer’s disease.
Professor Craig Ritchie is one of Scotland’s leading specialists in dementia research. He says that while these findings are “good although early”, we should keep in mind that the American research was done using a mouse model. In the brain of a person with Alzheimer’s disease, various molecular and cellular changes take place. The beta-amyloid protein involved comes in several different molecular forms that collect between neurons and generally appear in the brain about 15-20 years before the onset of dementia. One form called the beta-amyloid 42 is toxic and is known to disrupt cell function in the Alzheimer’s brain by clustering together to form plaques that gather between neurons. The proteins TREM2 and IL-33 are important to the ability of the brain’s immune cells to consume dead cells and other debris like the beta-amyloid plaque that piles up in patients’ brains, and levels of both are decreased in Alzheimer’s.
The study conducted by the Medical College of Georgia at Augusta University found that CBD played a great role and increased levels of TREM2 by seven times and IL-33 by ten times in mice. It also reduced levels of the immune protein IL-6, which is associated with the high inflammation levels. CBD can help with the symptoms like stiffness and impaired gate usually experienced by those with Alzheimer’s. While CBD is already being used to treat a wide range of health problems, it is great to see science backing CBD’s proficiency up. With more high-level studies, we will learn more about CBD and its capabilities.
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