Is Using CBD A Solution For Pain Relief During Chemotherapy?
Prescription opioid misuse is one of the most common types of illicit drug use in the U.S. The worst of it is that we only know prescription opioids to be effective for severe acute pain and there is no data on its efficacy for long-term pain management. It is also highly addictive. CBD has emerged as an alternative as researchers search for alternative pain relievers but one which comes with its limitations. Studies have shown that while CBD reduces pain sensation in animals, its ability to do so in humans is limited by low bioavailability, or the extent to which the drug successfully reaches its site of action.
Scientists from Temple University’s Lewis Katz School of Medicine and Doylestown-based biopharmaceutical company Neuropathix recently found that a new CBD analog drug could be the solution to this problem. The team tested this out on an animal model using mice. When tested on mice, their compound, KLS-13019, demonstrated both prevention and reversal of chemotherapy-induced peripheral neuropathy (CIPN), a common side effect of certain cancer treatments that damage peripheral nerves, which carry sensory information to the arms, legs, and brain. This discovery has the potential to prevent neural damage and neural degeneration in humans. The KLS-13019 compound was developed to optimize CBD’s properties and make its interaction with the human body more precise.
CBD is currently in clinical trials for the treatment of opioid craving, anxiety, and relapse during abstinence, so we were interested to see whether or not KLS-13019 might share some of that promise.
KLS-13019 is eight times more likely to get into the circulatory systems than CBD and it is also five times more water-soluble than CBD. In terms of differences between these compounds, CBD is pretty ineffective in reversing pain but KLS-13019 has demonstrated the reversing of neuropathic pain and effective in bringing the sensitivity reaction back to controlled levels. KLS-13019 was also successful in interrupting opiate reinforcement in animals. The next step with the CBD analog drug would be to initiate clinical tests on humans with FDA approval. Besides neuropathic pain, the team looked at other benefits of KLS-13019 as well.
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CBD is one of many powerful cannabinoids found in hemp known for helping to support our body and mind. Here at Healing Dragon CBD we do not intend to make unfounded medical claims about the health benefits of CBD. The FDA has not confirmed that CBD cures, treats, or prevents any diseases or conditions. Please take a moment to read our full disclosure statement.