Is CBD The Best Alternative For Those Seeking Improvement In Adult Treatment-Resistant Epilepsy Patients?
CBD’s popularity as a treatment option is growing steadily, given its lack of major side effects and a significant improvement in the quality of life. Recently, a study was conducted to understand how CBD affected the quality of life (QOL) of a sample of adult patients diagnosed with treatment-resistant forms of epilepsy.
Treatment-resistant epilepsy is generally associated with reduced QOL as symptoms are extremely difficult to manage, often resulting in extremely high seizure frequency as well as negative effects on mental health, physical functioning, and social activity.
While CBD treatment has been associated with improved QOL in epilepsy patients, it remains unclear if such improvements are independent of improvements in seizure control. The hypothesis behind the study was that the QOL would improve regardless of any changes in seizure frequency (SF) or severity, mood, or adverse events.
Increased seizure frequency and severity, anxiety, depression, longer duration of seizures, and adverse events are significant predictors of poor ratings in quality of life. Over the course of the study, the researchers found that total seizure counts saw a statistically significant improvement. These results support the findings of previous studies, indicating that CBD can be an effective add-on therapy to reduce seizure frequency in epilepsy patients.
The researchers found that the participants enjoyed a better QOLIE-89 score, positive POMS Total Mood Disturbance (TMD) and AEP scores, and lower mood-related problems. While CBD appears to approve patient outcome for a number of measures (QOL, mood, seizure frequency and severity, and adverse events), these changes appear to be largely independent of each other. The team concludes that these findings support their primary hypothesis and warrants digging deeper into this.
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